This is normally caused by one of two things. Either your email client does not have authentication turned on for sending mail to the outgoing mail server or your ISP is blocking your ablity to send email to 3rd party mail servers. Make sure you have the authentication turned on and if you still can not send email please contact your ISP to see if they block your ablity to send outgoing email on port 25. You can try changing port 25 to port 26, we have enabled port 26 as a work around for this issue.
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